Siozam

Siozam uses

• Pharmacological action
• Pharmacokinetics
• Why is Siozam prescribed?
• Dosage and administration
• Siozam side effects, adverse reactions
• Siozam contraindications
• Using during pregnancy and breastfeeding
• Special instructions
• Siozam drug interactions
• Siozam in case of emergency / overdose
• Siozam reviews

Pharmacological action

Siozam is an antidepressant. The mechanism of action is associated with selective blockade of the inverse of neuronal serotonin in the synapses of neurons of the CNS. Siozam lacks or has a very weak ability to bind to histamine, m-choline- and adrenoreceptors.

Pharmacokinetics

After oral administration C_max of Siozam in plasma is achieved within 2-4 hours. The oral bioavailability is about 80%. Changes in plasma concentrations of Siozam are linear. C_ss in the plasma is established within 1-2 weeks of therapy.

Binding to plasma proteins is less than 80%.

In blood plasma Siozam is present mainly in unchanged form. This drug is metabolized by demethylation, deamination and oxidation.

T_1/2 is 1.5 days.

Siozam is excreted by the kidneys and the bowel.

Why is Siozam prescribed?

Depression of various etiologies, panic disorder, obsessive-compulsive disorder.

Dosage and administration

Siozam is taken oral 1 time / day.

For adults depending on the evidence the initial dose of Siozam is 10-20 mg / day, if necessary, it may be increased up to 60 mg / day. For patients older than 65 years the dose is 20 mg / day, if necessary, it may be increase to 40 mg / day.

Siozam side effects, adverse reactions

Digestive system: frequently - dry mouth, nausea.

CNS: frequently - drowsiness, tremor, and in rare cases - seizures.

Cardiovascular system: possible slight decrease in heart rate.

Other: often - increased sweating.

Adverse reactions are usually transient and weakly expressed. They occur mainly during the first 2 weeks of treatment and usually decrease significantly with the improvement of the patient with depression.

Siozam contraindications

Hypersensitivity to Siozam; simultaneous taking MAO inhibitors.

Using during pregnancy and breastfeeding

Safety of Siozam during pregnancy and lactation has not been established. Use of the drug is justified only in cases where the potential benefits of therapy to the mother justifies the potential risk to the fetus and child.

In experimental studies there was revealed no teratogenic effects and any effect of Siozam on reproduction and prenatal development of the fetus.

Special instructions

In patients with liver failure Siozam should be used in minimal doses.

At weak and moderate renal insufficiency it does not require correction of dosing regimen of Siozam Meliapharm, the information on the application in severe renal failure is absent.

During the treatment period with Siozam it is possibly a slight decrease in heart rate that has no clinical significance, however, patients with initially reduced heart rate Siozam may cause a more pronounced bradycardia.

The efficacy and safety of Siozam in children has not been established.

Siozam should not be used concurrently with MAO inhibitors.

Patients should be prescribed with care for Siozam in highest dose and high doses of cimetidine.

It should be borne in mind that patients with depression are often a decrease in ability to concentrate which can be exacerbated by the use of psychotropic drugs.

Siozam drug interactions

Simultaneous administration of Siozam with: