Pharma company: vertex

List of vertex products:

• Aciclovir - Pharmacological action Aciclovir is an antiviral agent. Thymidine kinase of virus-infected cells actively converts acyclovir through a series of sequential reactions in the mono-, di- and triphosphate of acyclovir. The latter interacts with the viral DNA polymerase, and embedded in DNA, which is synthesized for new viruses. Thus it is formed a "defective" viral DNA which leads to suppression of replication of new generations of viruses. This mediciine acyclovir is active against Herpes...
• Amlodipine - Amlodipine is a long-acting 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, amlodipine prevents calcium-dependent myocyte contraction and vasoconstriction. A second proposed mechanism for the drug’s vasodilatory effects involves pH-dependent inhibition of calcium influx via inhibition of smooth...
• Amoxicillin - 1.1 Infections of the Ear, Nose, and Throat Amoxicillin tablets are indicated in the treatment of infections due to susceptible (ONLY β-lactamase-negative) isolates of Streptococcus species. (α- and β-hemolytic isolates only), Streptococcus pneumoniae, Staphylococcus spp., or Haemophilus influenzae. 1.2 Infections of the Genitourinary Tract Amoxicillin tablets are indicated in the treatment of infections due to susceptible (ONLY...
• Asniton
• Aspikor
• Azithromycin - Pharmacological action Azithromycin is a macrolide antibiotic of azalides group. Azithromycin inhibits RNA-dependent protein synthesis of sensitive microorganisms. It active against gram-positive bacteria: Staphylococcus aureus, Streptococcus spp. (including Streptococcus pneumoniae, Streptococcus pyogenes group A); gram-negative bacteria: Haemophilus influenzae, Haemophilus parainfluenzae, Haemophilus ducreyi, Moraxella catarrhalis, Escherichia coli, Bordetella pertussis, Bordetella...
• Carvedilol - Carvedilol information Carvedilol is a blood pressure medication and belongs to the class of drugs known as beta-blockers. These beta-blockers affect the circulatory system, which includes the human heart, arteries and veins. Carvedilol indications This medication is used primarily in treating hypertension or high blood pressure. Carvedilol warnings Taking Carvedilol may not be advisable if you have any of the following conditions: asthma heart problems such as low blood pressure...
• Clarithromycin - DESCRIPTION Clarithromycin is a semi-synthetic macrolide antibiotic. Chemically, it is 6-0-methylerythromycin. The molecular formula is C 38 H 69 NO 13 , and the molecular weight is 747.96. CLINICAL PHARMACOLOGYPharmacokinetics Clarithromycin is rapidly absorbed from the gastrointestinal tract after oral administration. The absolute bioavailability...
• Clindamycin - ZydaClin™ (clindamycin) Oral Drops liquid For Use in Dogs & Cats Equivalent to 25 mg per mL clindamycin ...
• Clotrimazole - Pharmacological action Clotrimazole is an antifungal agent of imidazole derivatives group for topical use. This medication has an effect at the expense of the synthesis of ergosterol, which is part of the cell membrane of fungi. Clotrimazole has a broad spectrum of action. Clotrimazole is active against dermatophytes, molds, fungi of the genus Candida, Malassezia furfur. This drug is also active against Corynebacterium minutissimum, Streptococcus spp., Staphylococcus spp., Trichomonas...
• Dexpanthenol - NDC 54925-064-10 DEXPANTHENOL INJECTION Net Contents: 100 mL FOR ANIMAL USE ONLY KEEP OUT OF REACH OF CHILDREN CAUTION: ...
• Hydrochlorothiazide - Hydrochlorothiazide information Hydrochlorothiazide is an antihypertensive, diuretic drug that acts on the electrolyte reabsorption in the renal tubular mechanism increasing the excretion of chloride and sodium in equivalent amounts. The exact mechanism of its antihypertensive action is not known at this time. Hydrochlorothiazide indications Hydrochlorothiazide is typically employed for the treatment of patients suffering from hypertension, either as monotherapy or in combination with...
• Ibuprofen - SPL UNCLASSIFIED SECTION Rx Only Cardiovascular Risk • NSAIDs may cause an increased risk of serious cardiovascular thrombotic events,...
• Indapamid
• Itrazol
• Ketoprofen - Pharmacological action Ketoprofen is a NSAID, propionic acid derivative. This medication has analgesic, anti-inflammatory and antipyretic activity. The mechanism of action is associated with inhibition of COX activity - the main enzyme metabolism of arachidonic acid, a precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever. A pronounced analgesic effect of ketoprofen is due to two mechanisms: peripheral (indirect, via inhibition of...
• Ketorolac - A pyrrolizine carboxylic acid derivative structurally related to indomethacin. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed) Indication: For the short-term (~5 days) management of moderately severe acute pain that requires analgesia at the opioid level, usually in a postoperative setting. Ketorolac, an antiinflammatory agent with analgesic and antipyretic properties, is used to treat osteoarthritis and control acute pain....
• Meloxicam - WARNING: RISK OF SERIOUS CARDIOVASCULAR and GASTROINTESTINAL EVENTS Cardiovascular Risk Nonsteroidal anti-inflammatory drugs (NSAIDs) may cause an increased risk of serious cardiovascular (CV) thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may increase with duration of use....
• Ortophen
• Perindopril - Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration. Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS)....
• Piracetam
• Piroxicam - Pharmacological action Piroxicam is a NSAID, refers to a group oxicams. This medication has anti-inflammatory, analgesic and antipyretic effect. The mechanism of action associated with inhibition of the enzyme COX, which leads to inhibition of prostaglandin synthesis from arachidonic acid. Piroxicam inhibits the aggregation of platelets. For systemic use this medicine reduces the pain syndrome. When Piroxicam used externally it weakens or suppresses inflammation and joint pain at rest...
• Ribavirin - WARNING: RISK OF SERIOUS DISORDERS AND RIBAVIRIN-ASSOCIATED EFFECTS WARNING: RISK OF SERIOUS DISORDERS AND RIBAVIRINASSOCIATED EFFECTS See full prescribing information for complete boxed warning. Ribavirin monotherapy, including...
• Simvastatin - Pharmacological action Simvastatin is a hypolipidemic agent from a group of statins, an inhibitor of HMG-CoA reductase. This medication is a prodrug because it has in its structure the closed lactone ring which is hydrolyzed after intake. Lipid-lowering effect of statins is associated with lower levels of total cholesterol by LDL-C. Reducing cholesterol is dose-dependent and is not linear but exponential. Statins do not affect the activity of lipoprotein and hepatic lipase, have no...
• Terbinafine - Terbinafine information Terbinafine is an antifungal drug used as athlete's foot medication. Terbinafine works like an antibiotic to treat fungal infections. Terbinafine indications This medicine is mainly indicated to treat fungal infections of the fingernails and toenails. Terbinafine may also be used for purposes not mentioned here. Terbinafine warnings This drug is classed as a FDA pregnancy category B drug and may cause severe side effects to an unborn baby. Consult with your...

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The information was verified by Dr. Rachana Salvi, MD Pharmacology