Tussidane

Tussidane uses

• Pharmacological action
• Pharmacokinetics
• Why is Tussidane prescribed?
• Dosage and administration
• Tussidane side effects, adverse reactions
• Tussidane contraindications
• Using during pregnancy and breastfeeding
• Special instructions
• Tussidane drug interactions
• Tussidane in case of emergency / overdose
• Tussidane reviews

Pharmacological action

Tussidane is an antitussive medication. Inhibiting the excitability of the cough center this medicine suppresses the cough of any origin. Tussidane has not addiction effects and it has no analgesic and hypnotic action. Tussidane starts to act after 10-30 minutes after oral administration, the duration of therapeutic action: 5-6 hours for adults and 6-9 hours for children. Tussidane is an optical isomer of levomethorphan which is similar to morphine. Due to optical isomerism this drug has no opioid effects. Tussidane used mainly for replacement of codeine as a cough suppressant. In addition to the cough suppressant this medication is used in medicine for diagnostic purposes and may be useful in various cases - from seizures to heroin addiction treatment, some chronic neurodegenerative diseases. These include amyotrophic lateral sclerosis (Charcot's disease), disease of "mad cow and other prion diseases. Tussidane has also been used for the treatment of mental retardation, Parkinson's disease, in the treatment of lung and other cancers and to prevent tissue rejection in transplantation because of the (poorly known) effects of sigma ligands on tumor cells and immune system.

Pharmacokinetics

After oral administration Tussidane is completely absorbed from the gastrointestinal tract. C_max of Tussidane in plasma is reached after 2 h. This medication biotransformes in the liver. Up to 45% of this drug is excreted by kidneys and there was considerable individual variation in rates of excretion of individual metabolites.

Why is Tussidane prescribed?

Dry cough of different etiology.

Dosage and administration

For adults and children over 12 years Tussidane prescribed on 15 mg 4 times / day, children aged 6 years - 7.5 mg 4 times / day.

Tussidane side effects, adverse reactions

Drowsiness, nausea, dizziness.

Tussidane contraindications

Bronchial asthma, bronchitis, simultaneous reception of mucolytic.

Using during pregnancy and breastfeeding

During pregnancy and lactation (breastfeeding) Tussidane prescribed with caution, only in cases where the expected therapeutic effect for the mother outweighs the potential risk to the fetus or child.

Special instructions

With carefully administered Tussidane with impaired liver function.

Tussidane drug interactions

MAO inhibitors when administered simultaneous with Tussidane may cause adrenergic crisis, collapse, coma, dizziness, agitation, increased blood pressure, hyperpyrexia, intracranial hemorrhage, lethargy, nausea, cramps, tremor. In combination with tricyclic antidepressants (amitriptyline, etc.) Tussidane may appeal serotonin syndrome and possible subsequent death. Amiodarone, fluoxetine, quinidine, inhibiting system cytochrome P450, may increase the drug concentration in the blood. Tobacco smoke can lead to increased secretion of glands in the background of inhibition of cough reflex. Some inhibitors of CYP450 (such as quinidine) increase and extended effects of this medicine.

Tussidane in case of emergency / overdose

Symptoms: excitement, dizziness, respiratory depression, impaired consciousness, decreased blood pressure, tachycardia, muscle hypertonicity, ataxia.

Treatment: mechanical ventilation, symptomatic agents.

Tussidane pharmaceutical active ingredients containing related brand and generic drugs:

• Dextromethorphan Hydrobromide

Tussidane available forms, composition, doses:

• Syrup; Oral; Dextromethorphan Hydrobromide 7.5 mg / 5 ml

Tussidane destination | category:

• Human:
• Antitussives
• Cough and cold preparations
• Expectorants

Tussidane Anatomical Therapeutic Chemical codes:

• R05DA09 - Dextromethorphan

Tussidane pharmaceutical companies:

• Elerte Laboratoire

References

1. Dailymed."ADULT WAL TUSSIN COUGH LONG ACTING (DEXTROMETHORPHAN HYDROBROMIDE) SOLUTION [WALGREEN COMPANY]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
2. Dailymed."DEXTROMETHORPHAN HYDROBROMIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
3. "dextromethorphan". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).

Frequently asked Questions

Depending on the reaction of the Tussidane after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Tussidane not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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The information was verified by Dr. Rachana Salvi, MD Pharmacology