Nortussine Adultes

Dextromethorphan Hydrobromide:

• Pharmacological action
• Pharmacokinetics
• Why is Nortussine Adultes prescribed?
• Dosage and administration
• Nortussine Adultes (Dextromethorphan Hydrobromide) side effects, adverse reactions
• Nortussine Adultes contraindications
• Using during pregnancy and breastfeeding
• Special instructions
• Nortussine Adultes drug interactions
• Nortussine Adultes in case of emergency / overdose
• Nortussine Adultes (Dextromethorphan Hydrobromide) reviews

Pharmacological action

Nortussine Adultes is an antitussive medication. Inhibiting the excitability of the cough center this medicine suppresses the cough of any origin. Nortussine Adultes (Dextromethorphan Hydrobromide) has not addiction effects and it has no analgesic and hypnotic action. Nortussine Adultes (Dextromethorphan Hydrobromide) starts to act after 10-30 minutes after oral administration, the duration of therapeutic action: 5-6 hours for adults and 6-9 hours for children. Nortussine Adultes (Dextromethorphan Hydrobromide) is an optical isomer of levomethorphan which is similar to morphine. Due to optical isomerism this drug has no opioid effects. Nortussine Adultes (Dextromethorphan Hydrobromide) used mainly for replacement of codeine as a cough suppressant. In addition to the cough suppressant this medication is used in medicine for diagnostic purposes and may be useful in various cases - from seizures to heroin addiction treatment, some chronic neurodegenerative diseases. These include amyotrophic lateral sclerosis (ALS) (Charcot's disease), disease of "mad cow and other prion diseases. Nortussine Adultes (Dextromethorphan Hydrobromide) has also been used for the treatment of mental retardation, Parkinson's disease, in the treatment of lung and other cancers and to prevent tissue rejection in transplantation because of the (poorly known) effects of sigma ligands on tumor cells and immune system.

Pharmacokinetics

After oral administration Nortussine Adultes (Dextromethorphan Hydrobromide) is completely absorbed from the gastrointestinal tract. C_max of Nortussine Adultes (Dextromethorphan Hydrobromide) in plasma is reached after 2 h. This medication biotransformes in the liver. Up to 45% of this drug is excreted by kidneys and there was considerable individual variation in rates of excretion of individual metabolites.

Why is Nortussine Adultes prescribed?

Dry cough of different etiology.

Dosage and administration

For adults and children over 12 years Nortussine Adultes prescribed on 15 mg 4 times / day, children aged 6 years - 7.5 mg 4 times / day.

Nortussine Adultes (Dextromethorphan Hydrobromide) side effects, adverse reactions

Drowsiness, nausea, dizziness.

Nortussine Adultes contraindications

Bronchial asthma, bronchitis, simultaneous reception of mucolytic.

Using during pregnancy and breastfeeding

During pregnancy and lactation (breastfeeding) Nortussine Adultes (Dextromethorphan Hydrobromide) prescribed with caution, only in cases where the expected therapeutic effect for the mother outweighs the potential risk to the fetus or child.

Special instructions

With carefully administered Nortussine Adultes (Dextromethorphan Hydrobromide) with impaired liver function.

Nortussine Adultes drug interactions

MAO inhibitors (including furazolidone, procarbazine, selegiline) when administered simultaneous with Nortussine Adultes (Dextromethorphan Hydrobromide) may cause adrenergic crisis, collapse, coma, dizziness, agitation, increased blood pressure, hyperpyrexia, intracranial hemorrhage, lethargy, nausea, cramps, tremor. In combination with tricyclic antidepressants (amitriptyline, etc.) Nortussine Adultes (Dextromethorphan Hydrobromide) may appeal serotonin syndrome and possible subsequent death. Amiodarone, fluoxetine, quinidine, inhibiting system cytochrome P450, may increase the drug concentration in the blood. Tobacco smoke can lead to increased secretion of glands in the background of inhibition of cough reflex. Some inhibitors of CYP450 (such as quinidine) increase and extended effects of this medicine.

Nortussine Adultes in case of emergency / overdose

Symptoms: excitement, dizziness, respiratory depression, impaired consciousness, decreased blood pressure, tachycardia, muscle hypertonicity, ataxia.

Treatment: mechanical ventilation, symptomatic agents.

Pyrilamine Maleate:

• Nortussine Adultes (Pyrilamine Maleate) reviews

For use when an oral antihistamine is needed.

Can be provided to horse: 1/2 ounce (1 tablespoon) per 1000lbs body weight. Can be repeated at 12 hour intervals as needed, or as recommended by a veterinarian. The large end of the enclosed scoop measures 1 tablespoon.

This product contains Nortussine Adultes (Pyrilamine Maleate) Maleate which may be prohibited in certain competition. Caution must be taken when used on competition horse subject to drug testing. Check with the event sanction body for the necessary withdrawal time.

EACH OUNCE CONTAINS (minimum): Nortussine Adultes (Pyrilamine Maleate) Maleat USP 600mg, in a palatable base.

FOR ANIMAL USE ONLY.

KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN.

Keep lid tightly closed and store in a dry place Do not store above 30 C (86 F).

NDC#: 65090-004-15

Nortussine Adultes (Pyrilamine Maleate)

Antihistamine Granules

Net Contents: 20 ounces (567 Gm)