Benylin Dry Coughs Original

Dextromethorphan Hydrobromide:

• Pharmacological action
• Pharmacokinetics
• Why is Benylin Dry Coughs Original prescribed?
• Dosage and administration
• Benylin Dry Coughs Original (Dextromethorphan Hydrobromide) side effects, adverse reactions
• Benylin Dry Coughs Original contraindications
• Using during pregnancy and breastfeeding
• Special instructions
• Benylin Dry Coughs Original drug interactions
• Benylin Dry Coughs Original in case of emergency / overdose
• Benylin Dry Coughs Original (Dextromethorphan Hydrobromide) reviews

Pharmacological action

Benylin Dry Coughs Original is an antitussive medication. Inhibiting the excitability of the cough center this medicine suppresses the cough of any origin. Benylin Dry Coughs Original (Dextromethorphan Hydrobromide) has not addiction effects and it has no analgesic and hypnotic action. Benylin Dry Coughs Original (Dextromethorphan Hydrobromide) starts to act after 10-30 minutes after oral administration, the duration of therapeutic action: 5-6 hours for adults and 6-9 hours for children. Benylin Dry Coughs Original (Dextromethorphan Hydrobromide) is an optical isomer of levomethorphan which is similar to morphine. Due to optical isomerism this drug has no opioid effects. Benylin Dry Coughs Original (Dextromethorphan Hydrobromide) used mainly for replacement of codeine as a cough suppressant. In addition to the cough suppressant this medication is used in medicine for diagnostic purposes and may be useful in various cases - from seizures to heroin addiction treatment, some chronic neurodegenerative diseases. These include amyotrophic lateral sclerosis (ALS) (Charcot's disease), disease of "mad cow and other prion diseases. Benylin Dry Coughs Original (Dextromethorphan Hydrobromide) has also been used for the treatment of mental retardation, Parkinson's disease, in the treatment of lung and other cancers and to prevent tissue rejection in transplantation because of the (poorly known) effects of sigma ligands on tumor cells and immune system.

Pharmacokinetics

After oral administration Benylin Dry Coughs Original (Dextromethorphan Hydrobromide) is completely absorbed from the gastrointestinal tract. C_max of Benylin Dry Coughs Original (Dextromethorphan Hydrobromide) in plasma is reached after 2 h. This medication biotransformes in the liver. Up to 45% of this drug is excreted by kidneys and there was considerable individual variation in rates of excretion of individual metabolites.

Why is Benylin Dry Coughs Original prescribed?

Dry cough of different etiology.

Dosage and administration

For adults and children over 12 years Benylin Dry Coughs Original prescribed on 15 mg 4 times / day, children aged 6 years - 7.5 mg 4 times / day.

Benylin Dry Coughs Original (Dextromethorphan Hydrobromide) side effects, adverse reactions

Drowsiness, nausea, dizziness.

Benylin Dry Coughs Original contraindications

Bronchial asthma, bronchitis, simultaneous reception of mucolytic.

Using during pregnancy and breastfeeding

During pregnancy and lactation (breastfeeding) Benylin Dry Coughs Original (Dextromethorphan Hydrobromide) prescribed with caution, only in cases where the expected therapeutic effect for the mother outweighs the potential risk to the fetus or child.

Special instructions

With carefully administered Benylin Dry Coughs Original (Dextromethorphan Hydrobromide) with impaired liver function.

Benylin Dry Coughs Original drug interactions

MAO inhibitors (including furazolidone, procarbazine, selegiline) when administered simultaneous with Benylin Dry Coughs Original (Dextromethorphan Hydrobromide) may cause adrenergic crisis, collapse, coma, dizziness, agitation, increased blood pressure, hyperpyrexia, intracranial hemorrhage, lethargy, nausea, cramps, tremor. In combination with tricyclic antidepressants (amitriptyline, etc.) Benylin Dry Coughs Original (Dextromethorphan Hydrobromide) may appeal serotonin syndrome and possible subsequent death. Amiodarone, fluoxetine, quinidine, inhibiting system cytochrome P450, may increase the drug concentration in the blood. Tobacco smoke can lead to increased secretion of glands in the background of inhibition of cough reflex. Some inhibitors of CYP450 (such as quinidine) increase and extended effects of this medicine.

Benylin Dry Coughs Original in case of emergency / overdose

Symptoms: excitement, dizziness, respiratory depression, impaired consciousness, decreased blood pressure, tachycardia, muscle hypertonicity, ataxia.

Treatment: mechanical ventilation, symptomatic agents.

Diphenhydramine Hydrochloride:

• Pharmacological action
• Pharmacokinetics
• Why is Benylin Dry Coughs Original Xepa-Soul Pattinson prescribed?
• Dosage and administration
• Benylin Dry Coughs Original (Diphenhydramine Hydrochloride) Xepa-Soul Pattinson side effects, adverse reactions
• Benylin Dry Coughs Original Xepa-Soul Pattinson contraindications
• Using during pregnancy and breastfeeding
• Special instructions
• Precautionary measures
• Benylin Dry Coughs Original (Diphenhydramine Hydrochloride) Xepa-Soul Pattinson drug interactions
• Benylin Dry Coughs Original Xepa-Soul Pattinson in case of emergency / overdose
• Benylin Dry Coughs Original (Diphenhydramine Hydrochloride) reviews

Pharmacological action

Benylin Dry Coughs Original Xepa-Soul Pattinson is a blocker of histamine H1-receptors. It has antiallergic activity, has a local anesthetic, antispasmodic and mild ganglion blocking action.

When Benylin Dry Coughs Original (Diphenhydramine Hydrochloride) Xepa-Soul Pattinson administered orally Benylin Dry Coughs Original (Diphenhydramine Hydrochloride) has a sedative and hypnotic effects, has a moderate antiemetic effect and has a central holinoliticheskoy activity.

When applied externally it has antiallergic effect.

Pharmacokinetics

Benylin Dry Coughs Original (Diphenhydramine Hydrochloride) Xepa-Soul Pattinson is rapidly absorbed from the gastrointestinal tract. Bioavailability is 50%. C_max is achieved after 20-40 min (in the greatest concentration is determined in the lungs, spleen, kidneys, liver, brain and muscles). Binding to plasma proteins - 98-99%. Penetrates through the BBB. Metabolised mainly in the liver, partly - in the lungs and kidneys. T1/2 is 4-10 hours. Within one day completely removed kidneys as metabolites conjugated to glucuronic acid. Significant quantities are derived from milk and can cause sedation in infants (may be a paradoxical reaction characterized by hyperexcitability).

Why is Benylin Dry Coughs Original Xepa-Soul Pattinson prescribed?

Allergic reactions (urticaria, hay fever, angioedema), allergic conjunctivitis, vasomotor rhinitis, Henoch-Schonlein purpura, serum sickness, itchy dermatitis, sleep disorders (monotherapy or in combination with drugs), chorea, sea and air sickness, vomiting in pregnancy, Meniere's syndrome, premedication.

Dosage and administration

Oral, IV, IM, rectal, topical, intranasal, in the conjunctival sac. Oral dose of Benylin Dry Coughs Original Xepa-Soul Pattinson for adults is 30-50 mg 1-3 times / day. The treatment course is 10-15 days. As soporific - 50 mg at bedtime. IM in doses of 50-250 mg; IV in drip - 20-50 mg. When oral administered single dose for children under 1 year - 2-5 mg; from 2 to 5 years - 5-15 mg; of 6 to 12 years - 15-30 mg. Externally applied 1-2 times / day.

Benylin Dry Coughs Original (Diphenhydramine Hydrochloride) Xepa-Soul Pattinson side effects, adverse reactions

Possible: a short-term numbness in the oral mucosa, drowsiness, weakness, decrease in psychomotor speed of reaction in children may be a paradoxical development of insomnia, irritability, and euphoria.

Rarely: dizziness, headache, dry mouth, nausea, photosensitivity, paresis of accommodation, poor coordination of movements, tremor.

Benylin Dry Coughs Original Xepa-Soul Pattinson contraindications

Closure glaucoma, prostatic hypertrophy, stenosing peptic ulcer, stenosis of the bladder neck, bronchial asthma, epilepsy, hypersensitivity to Benylin Dry Coughs Original (Diphenhydramine Hydrochloride).

Using during pregnancy and breastfeeding

During pregnancy and lactation, Benylin Dry Coughs Original (Diphenhydramine Hydrochloride) used with caution, according to strict indications, when the expected therapeutic effect for the mother outweighs the potential risk to the fetus or infant.

Special instructions

With careful use Benylin Dry Coughs Original (Diphenhydramine Hydrochloride) during pregnancy and lactation.

During the period of treatment with Benylin Dry Coughs Original (Diphenhydramine Hydrochloride) Xepa-Soul Pattinson should not be exposed to solar radiation should be avoided alcohol.

Used with caution in patients involved in potentially dangerous activities requiring attention and rapid psychomotor reactions.

Precautionary measures

Benylin Dry Coughs Original Xepa-Soul Pattinson is not recommended for SC injection. Since Benylin Dry Coughs Original (Diphenhydramine Hydrochloride) has atropinopodobnym action should be cautious in its use: patients with recent respiratory infection in history (including asthma), increased intraocular pressure in hyperthyroidism, cardiovascular system, hypotension. Antihistamines drugs can reduce mental alertness as well as in adults and children and also cause agitation and hallucinations, convulsions and death in infants and children, especially in overdose. Precautions apply at age 60 and older because more likely to develop dizziness, sedation and hypotension. During treatment with Benylin Dry Coughs Original (Diphenhydramine Hydrochloride) should avoid sun exposure. Should not be used during the drivers of vehicles and people, trade is connected with increased concentration. In the period of treatment should avoid drinking alcoholic beverages.

Benylin Dry Coughs Original (Diphenhydramine Hydrochloride) Xepa-Soul Pattinson drug interactions

When Benylin Dry Coughs Original (Diphenhydramine Hydrochloride) Xepa-Soul Pattinson applied simultaneously increases the effects of ethanol and drugs that depress the central nervous system.

With simultaneous use of Benylin Dry Coughs Original (Diphenhydramine Hydrochloride) Xepa-Soul Pattinson and MAO inhibitors increase the anticholinergic activity of Benylin Dry Coughs Original (Diphenhydramine Hydrochloride).

The antagonistic interaction observed with a joint appointment with psychostimulants.

Reduces the effectiveness of apomorphine as an emetic in the treatment of poisoning. Intensifies anticholinergic effects of drugs with anticholinergic activity.

Benylin Dry Coughs Original Xepa-Soul Pattinson in case of emergency / overdose

Symptoms: dry mouth, difficulty breathing, persistent mydriasis, flushing, depression or excitement (more common in children), CNS confusion; children - the development of convulsions and death.

Treatment: induction of vomiting, gastric lavage, the prescription of activated charcoal, symptomatic and supportive therapy on a background of careful monitoring of respiration and blood pressure levels.