Actifed Toux Seche

Dextromethorphan Hydrobromide:

• Pharmacological action
• Pharmacokinetics
• Why is Actifed Toux Seche prescribed?
• Dosage and administration
• Actifed Toux Seche (Dextromethorphan Hydrobromide) side effects, adverse reactions
• Actifed Toux Seche contraindications
• Using during pregnancy and breastfeeding
• Special instructions
• Actifed Toux Seche drug interactions
• Actifed Toux Seche in case of emergency / overdose
• Actifed Toux Seche (Dextromethorphan Hydrobromide) reviews

Pharmacological action

Actifed Toux Seche is an antitussive medication. Inhibiting the excitability of the cough center this medicine suppresses the cough of any origin. Actifed Toux Seche (Dextromethorphan Hydrobromide) has not addiction effects and it has no analgesic and hypnotic action. Actifed Toux Seche (Dextromethorphan Hydrobromide) starts to act after 10-30 minutes after oral administration, the duration of therapeutic action: 5-6 hours for adults and 6-9 hours for children. Actifed Toux Seche (Dextromethorphan Hydrobromide) is an optical isomer of levomethorphan which is similar to morphine. Due to optical isomerism this drug has no opioid effects. Actifed Toux Seche (Dextromethorphan Hydrobromide) used mainly for replacement of codeine as a cough suppressant. In addition to the cough suppressant this medication is used in medicine for diagnostic purposes and may be useful in various cases - from seizures to heroin addiction treatment, some chronic neurodegenerative diseases. These include amyotrophic lateral sclerosis (ALS) (Charcot's disease), disease of "mad cow and other prion diseases. Actifed Toux Seche (Dextromethorphan Hydrobromide) has also been used for the treatment of mental retardation, Parkinson's disease, in the treatment of lung and other cancers and to prevent tissue rejection in transplantation because of the (poorly known) effects of sigma ligands on tumor cells and immune system.

Pharmacokinetics

After oral administration Actifed Toux Seche (Dextromethorphan Hydrobromide) is completely absorbed from the gastrointestinal tract. C_max of Actifed Toux Seche (Dextromethorphan Hydrobromide) in plasma is reached after 2 h. This medication biotransformes in the liver. Up to 45% of this drug is excreted by kidneys and there was considerable individual variation in rates of excretion of individual metabolites.

Why is Actifed Toux Seche prescribed?

Dry cough of different etiology.

Dosage and administration

For adults and children over 12 years Actifed Toux Seche prescribed on 15 mg 4 times / day, children aged 6 years - 7.5 mg 4 times / day.

Actifed Toux Seche (Dextromethorphan Hydrobromide) side effects, adverse reactions

Drowsiness, nausea, dizziness.

Actifed Toux Seche contraindications

Bronchial asthma, bronchitis, simultaneous reception of mucolytic.

Using during pregnancy and breastfeeding

During pregnancy and lactation (breastfeeding) Actifed Toux Seche (Dextromethorphan Hydrobromide) prescribed with caution, only in cases where the expected therapeutic effect for the mother outweighs the potential risk to the fetus or child.

Special instructions

With carefully administered Actifed Toux Seche (Dextromethorphan Hydrobromide) with impaired liver function.

Actifed Toux Seche drug interactions

MAO inhibitors (including furazolidone, procarbazine, selegiline) when administered simultaneous with Actifed Toux Seche (Dextromethorphan Hydrobromide) may cause adrenergic crisis, collapse, coma, dizziness, agitation, increased blood pressure, hyperpyrexia, intracranial hemorrhage, lethargy, nausea, cramps, tremor. In combination with tricyclic antidepressants (amitriptyline, etc.) Actifed Toux Seche (Dextromethorphan Hydrobromide) may appeal serotonin syndrome and possible subsequent death. Amiodarone, fluoxetine, quinidine, inhibiting system cytochrome P450, may increase the drug concentration in the blood. Tobacco smoke can lead to increased secretion of glands in the background of inhibition of cough reflex. Some inhibitors of CYP450 (such as quinidine) increase and extended effects of this medicine.

Actifed Toux Seche in case of emergency / overdose

Symptoms: excitement, dizziness, respiratory depression, impaired consciousness, decreased blood pressure, tachycardia, muscle hypertonicity, ataxia.

Treatment: mechanical ventilation, symptomatic agents.

Triprolidine Hydrochloride:

• Actifed Toux Seche (Triprolidine Hydrochloride) reviews

Indication: For the symptomatic relief of seasonal or perennial allergic rhinitis or nonallergic rhinitis; allergic conjunctivitis; and mild, uncomplicated allergic skin manifestations of urticaria and angioedema. Also used in combination with other agents for the symptomatic relief of symptoms associated with the common cold.

In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Actifed Toux Seche (Triprolidine Hydrochloride), is a histamine H1 antagonist that competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies. Actifed Toux Seche (Triprolidine Hydrochloride) has anticholinergic and sedative effects.