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Rheumatrex

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Rheumatrex uses


WARNING: SEVERE TOXIC REACTIONS, INCLUDING EMBRYO-FETAL TOXICITY

Rheumatrex can cause the following severe or fatal adverse reactions.

Monitor closely and modify dose or discontinue Rheumatrex as appropriate.


WARNING: SEVERE TOXIC REACTIONS, INCLUDING EMBRYO-FETAL TOXICITY

See full prescribing information for complete boxed warning.

1 INDICATIONS AND USAGE

Rheumatrex is a folate analog metabolic inhibitor indicated for the:

1.1 Acute Lymphoblastic Leukemia

Rheumatrex is indicated for the treatment of pediatric patients with acute lymphoblastic leukemia (ALL) as part of a multi-phase, combination chemotherapy maintenance regimen.

1.2 Polyarticular Juvenile Idiopathic Arthritis

Rheumatrex is indicated in the management of pediatric patients with active polyarticular juvenile idiopathic arthritis (pJIA) who have had an insufficient therapeutic response to, or are intolerant of, an adequate trial of first-line therapy including full dose non-steroidal anti-inflammatory agents (NSAIDs).

2 DOSAGE AND ADMINISTRATION


Recommended

Dosage:

2.1 Important Administration Information

Rheumatrex is intended for oral use only. Use another formulation of Rheumatrex for alternative dosing in patients who require dosing via other routes of administration. Instruct patients and caregivers that the recommended dose should be taken weekly, as directed, and that mistaken daily use of the recommended dose has led to fatal toxicity .

It is important that Rheumatrex be measured with an accurate measuring device . A household teaspoon is not an accurate measuring device. A pharmacist can provide an appropriate device and can provide instructions for measuring the correct dose.

2.2 Acute Lymphoblastic Leukemia

The recommended starting dose of Rheumatrex, in multi-agent combination chemotherapy maintenance regimens, is 20 mg/m2 given one time weekly. After initiating Rheumatrex, continuation of appropriate dosing requires periodic monitoring of absolute neutrophil count and platelet count to assure sufficient drug exposure (that is to maintain ANC at a desirable level) and to adjust for excessive hematological toxicity.

2.3 Polyarticular Juvenile Idiopathic Arthritis

The recommended starting dose of Rheumatrex is 10 mg/m2 given one time weekly.

Dosages should be tailored to the individual patient and adjusted gradually to achieve an optimal response. Although there is experience with doses up to 30 mg/m2/week in pediatric patients, doses greater than 20 mg/m2/week may result in a significant increase in the incidence and severity of serious toxic reactions, especially bone marrow suppression. Doses between 20 and 30 mg/m2/week (0.65 to 1 mg/kg/week) may have better absorption and fewer gastrointestinal side effects if Rheumatrex is administered by an alternative route using another formulation.

Therapeutic response usually begins within 3 to 6 weeks and the patient may continue to improve for another 12 weeks or more.

Certain side effects such as mouth sores may be reduced by folate supplementation with Rheumatrex in pJIA.

2.4 Evaluations Prior to Starting Rheumatrex

Assess hematologic, hepatic, and renal function before beginning, as well as periodically during and before reinstituting, therapy with Rheumatrex . Exclude pregnancy in females of reproductive potential before starting Rheumatrex .

2.5 Handling Information

Rheumatrex is a cytotoxic drug. Follow applicable special handling and disposal procedures.1

3 DOSAGE FORMS AND STRENGTHS

Rheumatrex is a clear yellow to orange oral solution that contains 2.5 mg of Rheumatrex per milliliter.

Oral solution: 2.5 mg/mL (3)

4 CONTRAINDICATIONS

Rheumatrex is contraindicated in the following:

5 WARNINGS AND PRECAUTIONS

5.1 Bone Marrow Suppression

Rheumatrex suppresses hematopoiesis and can cause severe and life-threatening pancytopenia, anemia, leukopenia, neutropenia, and thrombocytopenia.

Obtain blood counts at baseline and periodically during treatment. Monitor patients for possible clinical complications of bone marrow suppression. Provide supportive care and modify dose or discontinue Rheumatrex as needed.

5.2 Serious Infections

Patients treated with Rheumatrex are at increased risk for developing life-threatening or fatal bacterial, fungal, or viral infections including opportunistic infections such as Pneumocystis jiroveci pneumonia, invasive fungal infections, hepatitis B reactivation, tuberculosis primary infection or reactivation, and disseminated Herpes zoster and cytomegalovirus infections.

Monitor patients for the signs and symptoms of infection during and after treatment with Rheumatrex and treat promptly. Consider dose modification or discontinuation of Rheumatrex in patients who develop serious infections .

5.3 Renal Toxicity and Increased Toxicity with Renal Impairment

Rheumatrex can cause renal damage including acute renal failure. Monitor renal function to decrease the risk of renal injury and mitigate renal toxicity.

Consider administration of glucarpidase in patients with toxic plasma Rheumatrex concentrations (> 1 micromole per liter) and delayed clearance due to impaired renal function .

5.4 Gastrointestinal Toxicity

Rheumatrex can cause diarrhea, vomiting, stomatitis, hemorrhagic enteritis, and fatal intestinal perforation. Patients with peptic ulcer disease or ulcerative colitis are at a greater risk of developing severe gastrointestinal adverse reactions.

Interrupt or discontinue Rheumatrex and institute appropriate supportive care as needed.

Unexpectedly severe and fatal gastrointestinal toxicity can occur with concomitant administration of Rheumatrex and nonsteroidal anti-inflammatory drugs (NSAIDs) .

5.5 Hepatic Toxicity

Rheumatrex can cause severe and potentially irreversible hepatotoxicity including fibrosis, cirrhosis, and fatal liver failure. Avoid use of Rheumatrex in patients with chronic liver disease.

Assess liver function prior to initiating Rheumatrex and monitor liver function tests during treatment. Interrupt or discontinue Rheumatrex as appropriate. Transient asymptomatic acute liver enzyme elevations are common and are not predictive of subsequent hepatic disease. Persistent abnormalities in liver function tests may precede appearance of fibrosis or cirrhosis.

Other risk factors for hepatotoxicity include alcoholism, obesity, diabetes, hyperlipidemia, previous significant exposure to liver toxins, history of liver disease, family history of inheritable liver disease, persistent abnormal liver chemistry findings, duration of therapy, and advanced age.

5.6 Pulmonary Toxicity

Methotrexate-induced pulmonary toxicity including acute or chronic interstitial pneumonitis and irreversible or fatal cases can occur at all dose levels. Monitor patients for signs of pulmonary toxicity and interrupt or discontinue Rheumatrex as appropriate.

5.7 Hypersensitivity and Dermatologic Reactions

Severe, including fatal, dermatologic reactions, such as toxic epidermal necrolysis, Stevens-Johnson syndrome, exfoliative dermatitis, skin necrosis, erythema multiforme, can occur with Rheumatrex. Discontinue Rheumatrex if severe dermatologic reactions occur.

Anaphylaxis can occur with Rheumatrex. If anaphylaxis or any other serious hypersensitivity reaction occurs, immediately discontinue Rheumatrex and institute appropriate therapy. Rheumatrex is contraindicated for use in patients with a history of severe hypersensitivity.

Radiation dermatitis and sunburn may be “recalled” by the use of Rheumatrex.

5.8 Secondary Malignancies

Secondary malignancies can occur at all dose levels of Rheumatrex.

There have been instances of lymphoproliferative disease associated with low-dose oral Rheumatrex which have regressed completely following withdrawal of Rheumatrex without institution of antineoplastic therapy. Discontinue Rheumatrex first and institute appropriate treatment if the lymphoma does not regress.

5.9 Embryo-Fetal Toxicity

Based on published reports and methotrexate’s mechanism of action, Rheumatrex can cause embryo-fetal toxicity and fetal death when administered to a pregnant woman. In pregnant women with non-malignant diseases, Rheumatrex is contraindicated. Consider the benefits and risks of Rheumatrex and risks to the fetus when prescribing Rheumatrex to a pregnant patient with a neoplastic disease. Advise females of reproductive potential to use effective contraception during therapy and for 6 months after the final dose. Advise males of reproductive potential to use effective contraception during and for at least 3 months after the final Rheumatrex dose .

5.10 Ineffective Immunization and Risks Associated with Live Vaccines

Immunization may be ineffective when given during Rheumatrex therapy.

Immunization with live virus vaccines is not recommended. There have been reports of disseminated vaccinia infections after smallpox immunization in patients receiving Rheumatrex therapy.

5.11 Effects on Reproduction

Based on published reports, Rheumatrex can cause impairment of fertility, oligospermia, and menstrual dysfunction. It is not known if the infertility is reversible in affected patients. Discuss the risk of effects on reproduction with female and male patients .

5.12 Increased Toxicity Due to ThirdSpace Accumulation

Rheumatrex can exit slowly from third‑space accumulations resulting in prolonged terminal plasma half-life and toxicity. Evacuate significant third-space accumulations prior to Rheumatrex administration .

5.13 Soft Tissue and Bone Toxicity with Radiation Therapy

Concomitant radiation therapy increases the risk of soft tissue necrosis and osteonecrosis associated with Rheumatrex.

5.14 Laboratory Tests

Closely monitor patients undergoing Rheumatrex therapy so that toxic effects are detected promptly. In general, monitoring of the following parameters is recommended: hematology at least monthly, renal function and liver function every 1 to 2 months [see Warnings and Precautions ].

Increase monitoring frequency during initial dosing, dose changes, or during periods of increased risk of elevated Rheumatrex blood levels (e.g., dehydration).

Liver Function Tests

Transient liver function test abnormalities are observed frequently after Rheumatrex administration and are usually not cause for modification of Rheumatrex therapy. Persistent liver function test abnormalities, and/or depression of serum albumin may be indicators of serious liver toxicity and require evaluation .

Pulmonary Function Tests

Pulmonary function tests may be useful if methotrexate-induced lung disease is suspected, especially if baseline measurements are available .

5.15 Risk of Improper Dosing

Both the physician and pharmacist should emphasize to the patient that the recommended dose is taken one time weekly, as directed, and that mistaken daily use of the recommended dose has led to fatal toxicity .

Advise patients to measure Rheumatrex with an accurate milliliter measuring device. Inform patients that a household teaspoon is not an accurate measuring device and could lead to overdosage, which can result in serious adverse reactions . Advise patients to ask their pharmacist to recommend an appropriate measuring device and for instructions for measuring the correct dose .

6 ADVERSE REACTIONS

The following adverse reactions are discussed in more detail in other sections of the labeling.


Most common adverse reactions are: ulcerative stomatitis, leukopenia, nausea, abdominal distress, and elevated liver function tests. Other frequently reported adverse reactions are malaise, fatigue, chills and fever, dizziness and decreased resistance to infection (6).

To report SUSPECTED ADVERSE REACTIONS, contact Silvergate Pharmaceuticals at 1-855-379-0383 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

6.1 Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug, and may not reflect the rates observed in practice.

The most frequently reported adverse reactions include ulcerative stomatitis, leukopenia, nausea, and abdominal distress. Other frequently reported adverse reactions are malaise, fatigue, chills, fever, dizziness, and decreased resistance to infection. Folate deficiency states may increase Rheumatrex toxicity.

Polyarticular Juvenile Idiopathic Arthritis

The approximate incidences of adverse reactions reported in pediatric patients with JIA treated with oral, weekly doses of Rheumatrex (5 to 20 mg/m2/week or 0.1 to 0.65 mg/kg/week) were as follows (virtually all patients were receiving concomitant nonsteroidal anti-inflammatory drugs, and some also were taking low doses of corticosteroids): elevated liver function tests, 14%; gastrointestinal reactions (e.g., nausea, vomiting, diarrhea), 11%; stomatitis, 2%; leukopenia, 2%; headache, 1.2%; alopecia, 0.5%; dizziness, 0.2%; and rash, 0.2%. Although there is experience with dosing up to 30 mg/m2/week in JIA, the published data for doses above 20 mg/m2/week are too limited to provide reliable estimates of adverse reaction rates.

6.2 Postmarketing Experience

Additional adverse reactions which have been identified during postmarketing use of Rheumatrex are listed below by organ system.

Blood and Lymphatic System Disorders: Suppressed hematopoiesis causing anemia, aplastic anemia, pancytopenia, leukopenia, neutropenia, thrombocytopenia, lymphaden-opathy, lymphoproliferative disorders (including reversible), hypogammaglobulinemia

Cardiovascular: Thromboembolic events (including arterial thrombosis, cerebral thrombosis, deep vein thrombosis, retinal vein thrombosis, thrombophlebitis, and pulmonary embolus), pericarditis, pericardial effusion, hypotension

Eye Disorders: Optic neuropathy, transient blindness, blurred vision, ocular irritation, conjunctivitis, xerophthalmia

Gastrointestinal Disorders: Gingivitis, pharyngitis, stomatitis, anorexia, nausea, vomiting, diarrhea, hematemesis, melena, gastrointestinal ulceration and bleeding, enteritis, pancreatitis

Hepatobiliary Disorders: Hepatotoxicity, acute hepatitis, chronic fibrosis and cirrhosis, decreased serum albumin, liver enzyme elevations

Immune System Disorders: Vasculitis, lymphomas, and anaphylactoid reactions

Infections: Fatal opportunistic infections (most commonly Pneumocystis jiroveci pneumonia). There have also been reports of other infections, pneumonia, sepsis, nocardiosis, histoplasmosis, cryptococcosis, Herpes zoster, Herpes simplex hepatitis, and disseminated Herpes simplex

Metabolism: Hyperglycemia and tumor lysis syndrome

Musculoskeletal System: Stress fracture, soft tissue necrosis, osteonecrosis, arthralgia, myalgia, osteoporosis

Nervous System Disorders: Headaches, drowsiness, blurred vision, transient blindness, speech impairment (including dysarthria and aphasia), hemiparesis, paresis and convulsions have also occurred following administration of Rheumatrex.

Following low doses, there have been reports of transient subtle cognitive dysfunction, mood alteration, unusual cranial sensations, leukoencephalopathy, or encephalopathy.

Renal Disorders: Azotemia, hematuria, proteinuria, cystitis

Reproductive Disorders: Defective oogenesis or spermatogenesis, menstrual dysfunction, loss of libido, impotence, vaginal discharge, gynecomastia

Respiratory Disorders: Pulmonary fibrosis, respiratory failure, chronic interstitial obstructive pulmonary disease, pleuritic pain and thickening alveolitis

Skin Disorders: Erythematous rashes, pruritus, urticaria, photosensitivity, pigmentary changes, alopecia, ecchymosis, telangiectasia, acne, furunculosis, erythema multiforme, toxic epidermal necrolysis, Stevens‑Johnson syndrome, skin necrosis, skin ulceration, accelerated nodulosis, and exfoliative dermatitis.

7 DRUG INTERACTIONS

7.1 Effect of Other Drugs on Rheumatrex

Oral Antibiotics

Penicillins may reduce the renal clearance of Rheumatrex; increased serum concentrations of Rheumatrex with concomitant hematologic and gastrointestinal toxicity have been observed with Rheumatrex. Monitor patients accordingly .

Trimethoprim/sulfamethoxazole has been reported to increase bone marrow suppression in patients receiving Rheumatrex. Monitor patients accordingly .

Hepatotoxins

The potential for increased hepatotoxicity when Rheumatrex is administered with other hepatotoxic agents has not been evaluated; however, hepatotoxicity has been reported in such cases. Monitor patients receiving Rheumatrex with other potential hepatotoxins (e.g., azathioprine, retinoids, and sulfasalazine) for possible signs of hepatotoxicity.

Probenecid

Probenecid may reduce renal elimination of Rheumatrex. Consider alternative drugs.

7.2 Effect of Rheumatrex on Other Drugs

Theophylline

Rheumatrex may decrease the clearance of theophylline. Monitor theophylline levels when coadministered with Rheumatrex.

8 USE IN SPECIFIC POPULATIONS

Lactation: Advise women not to breastfeed.

8.1 Pregnancy

Risk Summary

Based on published reports and methotrexate’s mechanism of action, Rheumatrex is a teratogen that can cause embryo-fetal toxicity and fetal death when administered to a pregnant woman . In pregnant women with non-malignant disease, Rheumatrex is contraindicated. Consider the benefits and risks of Rheumatrex and risks to the fetus when prescribing Rheumatrex to a pregnant patient with a neoplastic disease. There are no animal data that meet current standards for nonclinical developmental toxicity studies.

The estimated background risk of major birth defects and miscarriage for the indicated populations are unknown. In the U.S. general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2-4% and 15-20%, respectively.

Data

Human Data

Published data from cases, literature reviews, and observational studies report that Rheumatrex exposure during pregnancy is associated with an increased risk of embryo-fetal toxicity and fetal death. Rheumatrex exposure during the first trimester of pregnancy is associated with an increased incidence of spontaneous abortions and multiple adverse developmental outcomes, including skull anomalies, facial dysmorphism, central nervous system abnormalities, limb abnormalities, and sometimes cardiac anomalies and intellectual impairment. Adverse outcomes associated with exposure during second and third trimesters of pregnancy include intrauterine growth restriction and functional abnormalities. Because Rheumatrex is widely distributed and persists in the body for a prolonged period, there is a potential risk to the fetus from preconception Rheumatrex exposure.

A prospective multicenter study by U.S. and European teratology information services evaluated pregnancy outcomes in women taking Rheumatrex less than or equal to 30 mg/week after conception. The rate of spontaneous abortion/miscarriage in pregnant women exposed to Rheumatrex was 42.5% (95% confidence interval [95% CI] 29.2-58.7), which was higher than in unexposed autoimmune disease comparators (22.5%, 95% CI 16.8-29.7) and unexposed nonautoimmune disease comparators (17.3%, 95% CI 13-22.8). Of the live births, the rate of major birth defects in pregnant women exposed to Rheumatrex after conception was higher than in autoimmune disease comparators (adjusted odds ratio (OR) 1.8 [95% CI 0.6-5.7]) and nonautoimmune disease comparators (adjusted OR 3.1 [95% CI 1.03-9.5]). Major birth defects associated with pregnancies exposed to Rheumatrex after conception were not always consistent with methotrexate-associated adverse developmental outcomes.

8.2 Lactation

Risk Summary

Limited published literature report the presence of Rheumatrex in human milk in low amounts. The highest breast milk to plasma concentration ratio demonstrated was 0.08:1. No information is available on the effects of Rheumatrex on a breastfed infant or on milk production. Because of the potential for serious adverse reactions, including myelosuppression, from Rheumatrex in breastfed infants, advise women not to breastfeed during Rheumatrex therapy.

8.3 Females and Males of Reproductive Potential

Pregnancy Testing

Test for pregnancy prior to initiating therapy with Rheumatrex.

Contraception

Females

Rheumatrex can cause fetal harm when administered to a pregnant woman .

Advise females of reproductive potential to use effective contraception during and for 6 months after the final Rheumatrex dose.

Males

Rheumatrex can cause chromosomal damage to sperm cells. Advise males with female partners of reproductive potential to use effective contraception during and for at least 3 months after the final Rheumatrex dose.

Infertility

Females

Based on published reports of female infertility after therapy with Rheumatrex, advise females of reproductive potential that Rheumatrex can cause impairment of fertility and menstrual dysfunction during and after cessation of therapy. It is not known if the infertility may be reversed in all affected females.

Males

Based on published reports of male infertility after therapy with Rheumatrex, advise males of reproductive potential that Rheumatrex can cause oligospermia or infertility during and after cessation of therapy. It is not known if the infertility may be reversed in all affected males.

8.4 Pediatric Use

Safety and effectiveness of Rheumatrex in pediatric patients have been established for the treatment of pediatric patients with acute lymphoblastic leukemia as part of a multi-phase, combination chemotherapy maintenance regimen and for the management of pediatric patients with active polyarticular juvenile idiopathic arthritis (pJIA) .

8.6 Renal Impairment

Rheumatrex elimination is reduced in patients with impaired renal function. Monitor patients with renal impairment for an extended period of time. Consider a dose reduction or, in some cases, discontinue Rheumatrex administration .

8.7 Hepatic Impairment

The effect of hepatic impairment on Rheumatrex pharmacokinetics has not been studied. Patients with hepatic impairment may be more susceptible to hepatotoxicity . Consider dose adjustments or alternative treatments in patients with baseline hepatic impairment.

10 OVERDOSAGE

Manifestations

Fatal overdosage has occurred with Rheumatrex. Manifestations of overdosage include adverse reactions reported at pharmacologic doses, particularly hematologic and gastrointestinal reactions (e.g., leukopenia, thrombocytopenia, anemia, pancytopenia, bone marrow suppression, mucositis, stomatitis, oral ulceration, nausea, vomiting, gastrointestinal ulceration, or gastrointestinal bleeding). In some cases, no symptoms were reported.

Management

Leucovorin and levoleucovorin are indicated to diminish the toxicity and counteract the effect of inadvertently administered overdosages of Rheumatrex. Administer leucovorin or levoleucovorin as soon as possible after overdosage (refer to the leucovorin or levoleucovorin Prescribing Information). Monitor serum Rheumatrex concentrations closely to guide leucovorin or levoleucovorin therapy. Monitor serum creatinine concentrations closely because high serum Rheumatrex concentrations may cause renal damage leading to acute renal failure.

Glucarpidase is indicated for the treatment of toxic Rheumatrex concentrations in patients with delayed Rheumatrex clearance due to impaired renal function (refer to the glucarpidase prescribing information). If glucarpidase is used, do not administer leucovorin within 2 hours before or after a dose of glucarpidase because leucovorin is a substrate for glucarpidase.

In cases of massive overdosage, hydration and urinary alkalinization may be necessary to prevent the precipitation of Rheumatrex and/or its metabolites in the renal tubules. Neither hemodialysis nor peritoneal dialysis has been shown to improve Rheumatrex elimination. However, effective clearance of Rheumatrex has been reported with acute, intermittent hemodialysis using a high-flux dialyzer.

11 DESCRIPTION

Rheumatrex contains Rheumatrex, a folate analog metabolic inhibitor.

Chemically Rheumatrex is N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]-benzoyl]-L-glutamic acid. The structural formula is:

NDC 52652-2001-1

Rheumatrex

(methotrexate)

Oral Solution

2.5 mg/mL

For Oral Use Only

READY TO USE

120 mL

Silvergate

Pharmaceuticals Inc.

Rx Only

Each 1 mL contains 2.5 mg

Rheumatrex (equivalent to

2.74 mg Rheumatrex sodium).

Usual Dose:

See prescribing information.

Store refrigerated

2° - 8°C (36° - 46°F).

After dispensing, may be

stored at room temperature

15° - 30°C (59° - 86°F)

for 60 days.

KEEP THIS AND ALL

MEDICATIONS OUT OF THE

REACH OF CHILDREN

Manufactured for:

Silvergate Pharmaceuticals, Inc.

Greenwood Village, CO 80111

Lot:

EXp:

Rheumatrex pharmaceutical active ingredients containing related brand and generic drugs:


Rheumatrex available forms, composition, doses:


Rheumatrex destination | category:


Rheumatrex Anatomical Therapeutic Chemical codes:


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References

  1. Dailymed."METHOTREXATE (METHOTREXATE SODIUM) INJECTION, SOLUTION [FRESENIUS KABI USA, LLC]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  2. Dailymed."METHOTREXATE SODIUM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  3. "methotrexate". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming Rheumatrex?

Depending on the reaction of the Rheumatrex after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Rheumatrex not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Rheumatrex addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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sdrugs.com conducted a study on Rheumatrex, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Rheumatrex consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

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The information was verified by Dr. Rachana Salvi, MD Pharmacology


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