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DRUGS & SUPPLEMENTS
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Fastum
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Fastum uses
Pharmacological action
Fastum is a NSAID, propionic acid derivative. This medication has analgesic, anti-inflammatory and antipyretic activity. The mechanism of action is associated with inhibition of COX activity - the main enzyme metabolism of arachidonic acid, a precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever. A pronounced analgesic effect of Fastum is due to two mechanisms: peripheral and central (due to inhibition of prostaglandin synthesis in the central and peripheral nervous system, as well as the influence on the biological activity of other neurotrophic substances that play a key role in the release of neurotransmitters in the spinal pain brain). In addition, this drug has anti-bradykinin activity, stabilizes lysosomal membranes, causes a significant inhibition of neutrophils in patients with rheumatoid arthritis.
Pharmacokinetics
After oral and rectal administration Fastum is well absorbed from the gastrointestinal tract. Cmax in plasma by ingestion is achieved through 1-5 hours (depending on dosage form), with rectal administration - after 45-60 min; IM administration - after 20-30 min; IV injections - after 5 minutes.
The plasma protein binding is 99%. Due to the lipophilicity expressed rapidly penetrates the BBB. Css in plasma and cerebrospinal fluid stored between 2 and 18 h.
Fastum well penetrates into synovial fluid, where its concentration is 4 hours after admission exceeds that in plasma.
This medicine is metabolized by binding to glucuronic acid and to a lesser extent by hydroxylation.
Fastum is excreted primarily by kidneys and to a lesser extent through the intestines. T1/2 of Fastum from plasma after oral administration is 1.5-2 h; after rectal administration - about 2 hours; IM administration - 1.27 hours, IV injections - 2 hours.
Why is Fastum prescribed?
Articular syndrome ; symptomatic treatment of inflammatory and degenerative diseases of the musculoskeletal (shoulder, artrosinovit, tendonitis, tenosynovitis, bursitis, lumbago), back pain, neuralgia, myalgia. Uncomplicated trauma, particularly sports, sprains, sprain or rupture of ligaments and tendons, bruises, post-traumatic pain. As part of combination therapy of inflammatory diseases of veins, lymphatic vessels, lymph nodes (phlebitis, periflebit, lymphangitis, lymphadenitis surface).
Dosage and administration
The dosage regimen set individually according to the severity of the disease. For oral administration in adult the initial daily dose is 300 mg in 2-3 doses. For maintenance treatment the dose depends on the dosage form. For the treatment of acute conditions or exacerbations of chronic edema of the process this medication is administered in 100 mg as a single IM injection. Next Fastum administered orally or rectally.
Topically this drug used to the skin surface 2 times / day.
The maximum dose oral or rectal administration is 300 mg / day.
Fastum side effects, adverse reactions
Digestive system: epigastric pain, nausea, vomiting, constipation or diarrhea, anorexia, gastralgia, liver, rarely - erosive and ulcerative lesions of the gastrointestinal tract, gastrointestinal bleeding and perforation.
CNS: headache, dizziness, tinnitus and drowsiness.
Urinary system: kidney damage.
Allergic reactions: skin rash, rarely - bronchospasm.
Local reactions: when Fastum used in rectal suppositories it is possible irritation of the mucous membrane of the rectum, painful defecation, when this medication used in a gel form - itching, skin rash at the site of application.
Fastum contraindications
For oral administration: erosive and ulcerative lesions of the gastrointestinal tract in acute phase, "aspirin triad" expressed by the human liver and / or kidney disease; III trimester of pregnancy; age up of 15 years ; increased sensitivity to Fastum and salicylates.
For rectal administration: proctitis and bleeding from the rectum in history.
For external use: moist dermatitis, eczema, infected abrasions and wounds.
Using during pregnancy and breastfeeding
Fastum is contraindicated for use in the III trimester of pregnancy. In I and II trimesters of pregnancy the use of Fastum may be in cases when the potential benefit to the mother outweighs the potential risk to the fetus.
If necessary to use Fastum in lactating a breast-feeding should be stopped
.Category of the fetus by FDA - C.
Special instructions
With great caution use Fastum in patients with liver and kidney, gastrointestinal tract diseases in the history of dyspeptic symptoms after major surgery. In the course of treatment it requires systematic monitoring of liver and kidney.
Fastum drug interactions
When this drug applied simultaneously with:
- other NSAIDs increases the risk of erosive and ulcerative lesions of the gastrointestinal tract and bleeding
- antihypertensive drugs it may decreases their actions
- aspirin may decrease the binding of Fastum to plasma proteins and increase its plasma clearance
- heparin, ticlopidine increase risk of bleeding
- lithium therapy - it may increase the concentration of lithium in blood plasma to the toxic by reducing its renal excretion
- diuretics increases the risk of renal failure due to a decrease in renal blood flow caused by inhibition of prostaglandin synthesis, and against the background of hypovolemia
- probenecid it may decreases the clearance of Fastum and its binding to plasma proteins
- methotrexate - may increase the side effects of methotrexate
- warfarin may develop severe, sometimes fatal bleeding.
Fastum in case of emergency / overdose
Symptoms: lethargy, dizziness, nausea, vomiting, epigastric pain - these symptoms are usually reversible. May be respiratory distress, coma, convulsions. Rarely - bleeding from the gastrointestinal tract, hypotension / hypertension, acute renal failure.
Treatment: symptomatic and supportive therapy, monitoring of respiratory and cardiovascular systems. The is no a specific antidote. Hemodialysis is ineffective.
Fastum pharmaceutical active ingredients containing related brand and generic drugs:
Fastum available forms, composition, doses:
Fastum destination | category:
Fastum Anatomical Therapeutic Chemical codes:
Fastum pharmaceutical companies:
References
- Dailymed."KETOPROFEN CAPSULE [A-S MEDICATION SOLUTIONS]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
- Dailymed."KETOPROFEN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
- "ketoprofen". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
Frequently asked Questions
Can i drive or operate heavy machine after consuming Fastum?Depending on the reaction of the Fastum after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Fastum not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.
Is Fastum addictive or habit forming?Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
Review
sdrugs.com conducted a study on Fastum, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Fastum consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.Visitor reports
Visitor reported useful
No survey data has been collected yetVisitor reported side effects
No survey data has been collected yetOne visitor reported price estimates
What is your opinion about drug cost? Did you feel the cost is apt, or did you feel it is expensive?The report given by the sdrugs.com website users shows the following figures about several people who felt the medicine Fastum is expensive, and the medicine is not expensive. The results are mixed. The perception of the cost of the medicine to be expensive or not depends on the brand name of the medicine, country, and place where it is sold, and the affordability of the patient. You can choose a generic drug in the place of the branded drug to save the cost. The efficiency of the medicine will not vary if it is generic or a branded one.
| Visitors | % | ||
|---|---|---|---|
| Not expensive | 1 | 100.0% | |
Three visitors reported frequency of use
How often in a day do you take the medicine?Are you taking the Fastum drug as prescribed by the doctor?
Few medications can be taken Once in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sdrugs.com website users about the frequency of taking the drug Fastum is mentioned below.
| Visitors | % | ||
|---|---|---|---|
| Once in a day | 2 | 66.7% | |
| 3 times in a day | 1 | 33.3% | |
Three visitors reported doses
What is the dose of Fastum drug you are taking?According to the survey conducted among sdrugs.com website users, the maximum number of people are using the following dose 11-50mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
| Visitors | % | ||
|---|---|---|---|
| 11-50mg | 1 | 33.3% | |
| 51-100mg | 1 | 33.3% | |
| 201-500mg | 1 | 33.3% | |
Visitor reported time for results
No survey data has been collected yetVisitor reported administration
No survey data has been collected yetVisitor reported age
No survey data has been collected yetVisitor reviews
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The information was verified by Dr. Rachana Salvi, MD Pharmacology