Synovex C

Estradiol Benzoate:

• Synovex C information
• Synovex C indications
• Synovex C warnings
• Synovex C intake guidelines
• Synovex C dosage
• Synovex C overdose
• Synovex C missed dose
• Synovex C side effects
• Synovex C drug reactions
• Synovex C (Estradiol Benzoate) reviews

Synovex C information

Synovex C (Estradiol Benzoate) is a female sex hormone that regulates many functions in the female organism. This medicine is currently available under the form of tablets in two concentrations - 1 mg and 2 mg, respectively.

Synovex C indications

Synovex C (Estradiol Benzoate) is used for the treatment of menopausal symptoms such as vaginal dryness, irritation or burning, or hot flushes - other symptoms that are not listed here may be treated with this medicine as well. Also, this pharmaceutical preparation can be used as a prophylactic agent for the prevention of a medical condition known as osteoporosis in both female and male patients. In some cases, this medicine may also be employed in conjunction with other drugs as part of the treatment for certain types of cancer, both in the case of women and men.

There may be other uses for Synovex C (Estradiol Benzoate), which are not covered in this leaflet. If you are interested to find out more about the possible uses of this product, it is recommended that you consult with a pharmacist or a specialized physician.

Synovex C warnings

Synovex C (Estradiol Benzoate) should not be administered to patients that are suffering from any type of disorder involving blood clots, or from circulatory / cardiac disorders. Patients who present an undiagnosed, abnormal vaginal bleeding may not start taking this medicine until they undergo medical examination and receive their physician's approval. Also, patients that have uterine cancer, breast cancer or any type of hormone-dependant cancer may not start a treatment with Synovex C (Estradiol Benzoate).

Before you start a therapy course with this drug, it is strongly advised to inform your personal physician of any health problems you may be suffering from. In particular, affections such as hypertension, heart disease, angina, high triglyceride / cholesterol levels, renal or hepatic disease, asthma, migraines, epilepsy (or any other disorder involving seizures), diabetes or gallbladder disease should be mentioned, as well as past surgical procedures such as a hysterectomy. Patients suffering from these conditions may require special dosage adjustments or monitoring during the treatment.

Synovex C (Estradiol Benzoate) may not be administered during pregnancy. Also, for the duration of the therapy you will need to employ an effective, non-hormonal contraceptive method.

Pharmaceutical products based on Estradiol (including Synovex C (Estradiol Benzoate)) increase the patients' risk of developing an affection known as endometrial hyperplasia. This can be countered by administration of progestin medication. It is recommended that you consult with your doctor for more information.

Synovex C intake guidelines

You need to take Synovex C (Estradiol Benzoate) exactly as directed by your health care specialist. You may take the tablets with a glass of water or with food to reduce stomach upset; however you may not chew, crush or break the tablets.

While following a treatment course with Synovex C (Estradiol Benzoate) you will need to undergo regular medical examination, typically on a monthly basis. Also, you will need to regularly self-examine your breasts for the presence of lumps.

Synovex C dosage

Your health care specialist will determine the Synovex C (Estradiol Benzoate) dosage appropriate for your case by taking into consideration a number of factors, most of which are characteristic to you; as such, your medication dosage is very likely to be different from that of other patients'. Because of that, you should never use the Synovex C (Estradiol Benzoate) dosage that has been prescribed to another patient - you may not obtain the desired results unless you employ the medication dosage best suited for your situation.

At the same time, your physician will inform you regarding the duration of the Synovex C (Estradiol Benzoate) therapy and the number of daily intakes. Make sure that you understand all of his or her indications. If you have trouble understanding or remembering any of the dosage directions, you should ask your physician to assist you by providing additional information.

Synovex C overdose

If an overdose with Synovex C (Estradiol Benzoate) is suspected, immediately contact the nearest hospital as the patient may need emergency medical assistance. The most common signs of an overdose are vaginal bleeding, nausea and vomiting.

Synovex C missed dose

In the event that you miss taking one of your Synovex C (Estradiol Benzoate) doses, take it when you remember before returning to your normal dosing schedule. However, you should skip taking the missed dose if it is almost time for another dose of the medicine. Consult with your physician if you have missed two or more intakes.

Synovex C side effects

Side effects of a treatment with Synovex C (Estradiol Benzoate) include nausea and vomiting, loss of appetite, swelling of the breasts, sex drive changes, impotence (in the case of men), abnormal vaginal bleeding, vaginal dryness, discomfort or pain, break-through bleeding, menstrual period changes, jaundice, sudden weakness or numbness, breast lumps. These are not all the signs and symptoms that may appear. It is best that you check with your doctor at any point during the course of your therapy if anything unusual occurs.

Although uncommon, allergic reactions to Synovex C (Estradiol Benzoate) are possible. It is strongly recommended that you cease taking the medicine and contact your personal health care provider if you begin experiencing any of the characteristic symptoms - breathing difficulties, swelling of the throat, lips, tongue or face, rashes and hives.

Synovex C drug reactions

Synovex C (Estradiol Benzoate) may interact with Phenobarbital, Phenytoin, Ritonavir, Cimetidine, Carbamazepine, Rifampin, blood thinning agents such as Warfarin or with antibiotics (Clarithromycin, Erythromycin, Ketoconazole or Itraconazole). Also, this product may interact with the herbal remedy St. John's wort. These are not all the possible drug reactions; it is best that you tell your prescriber about any other drugs you are currently taking prior to starting your treatment. In most cases, an adjustment to the medication dosage will ensure the safety of the treatment, reducing the risk of accidental interactions.

Progesterone:

• Pharmacological action
• Pharmacokinetics
• Why is Synovex C prescribed?
• Dosage and administration
• Synovex C (Progesterone) side effects, adverse reactions
• Synovex C contraindications
• Using during pregnancy and breastfeeding
• Special instructions
• Synovex C drug interactions
• Synovex C (Progesterone) reviews

Pharmacological action

Synovex C is a progestogen. This medication causes a transition in the endometrium of proliferative phase, called follicular hormone in the secretory phase, and after fertilization promotes its transition to a state necessary for the development of a fertilized egg. Synovex C (Progesterone) reduces the excitability and contractility of the muscles of the uterus and fallopian tubes, stimulates the development of terminal elements of the breast. It has no androgenic activity. This drug has little effect on protein metabolism, promotes fat deposit and accumulation of glucose in the liver and reduces the reabsorption of sodium in renal tubules.

Synovex C (Progesterone) has a blocking effect on the secretion of hypothalamic factors LH and FSH release, inhibits the formation of the pituitary gonadotropin-releasing hormone and inhibits ovulation.

Pharmacokinetics

After IM injection Synovex C (Progesterone) is absorbed rapidly and almost completely. This medication metabolized in the liver, the majority of metabolites formed conjugates with glucuronic and sulfuric acids. T_1/2 from plasma is a few minutes. This medicine is excreted in the urine - 50-60%, in feces - more than 10%. The number of metabolites which are excreted in the urine varies, depending on the phase of the corpus luteum.

Why is Synovex C prescribed?

Capsules Oral - premenstrual syndrome, fibrocystic breast disease, premenopausal, menopause, including premature, postmenopausal women - as the progestogen component of hormone replacement therapy (HRT) in combination with estrogen; Capsules Vaginal - HRT when dormant in the absence of ovarian Synovex C (Progesterone) (egg donation), support the luteal phase in preparation for in vitro fertilization, support the luteal phase in spontaneous or induced menstrual cycle, prevention of habitual abortion by threatening and progestogen deficiency, endocrine infertility, prevention of uterine fibroids, endometriosis.

Solution in oil: amenorrhea, oligomenorrhea, algomenorrhea (on the basis of hypogenitalism), anovulatory metrorrhagia, infertility, endocrine (including failure of the corpus luteum), the threat of termination of pregnancy, diagnosis of estrogen.

Gel for external use: mammalgia, disease of the breast.

Dysfunctional uterine bleeding, metrorrhagia, amenorrhea, recurrent miscarriage.

Contraception.

Dosage and administration

Orally, intravaginally, IM, locally. The dosing regimen is individual. The dose, frequency and duration of treatment with Synovex C are determined according to the scheme depending on the indications and the clinical situation.

Synovex C (Progesterone) side effects, adverse reactions

Cardiovascular system: increased blood pressure.

Metabolic: edema.

Digestive system: liver problems, jaundice, rarely (with prolonged use) - nausea, vomiting.

Endocrine: rare (with prolonged use) - decreased libido, weight gain, pain and tension in the breasts, irregular uterine bleeding.

CNS: rare (with prolonged use) - headache, depression.

Synovex C contraindications

Severe liver or kidney problems, hepatitis, thromboembolic disease, vaginal bleeding of not established genesis, breast carcinoma (except for cases in which Synovex C (Progesterone) is used in a combination therapy of this disease).

Using during pregnancy and breastfeeding

In cases of extreme necessity Synovex C may be used during pregnancy in the established failure of the corpus luteum hormone.

Synovex C (Progesterone) is not used in women planning a pregnancy in the near future.

Special instructions

Synovex C (Progesterone) is used with caution in patients with cardiovascular disease, impaired liver or kidney problems, diabetes, asthma, epilepsy, migraine, depression.

Synovex C drug interactions

Synovex C (Progesterone) reduces the intensity of the drugs that stimulate the smooth muscles of the uterus, anabolic steroids, gonadotropin-releasing hormone of the anterior pituitary.

This medication reduces the lactogenic effect of oxytocin.

Synovex C (Progesterone) enhances the action of diuretics, antihypertensive drugs, immunosuppressive drugs. Simultaneous administration of Synovex C (Progesterone) with barbiturates it is marked decrease of Synovex C (Progesterone) effects.