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DRUGS & SUPPLEMENTS
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PK-Merz
How often in a day do you take medicine? How many times? |
PK-Merz uses
Pharmacological action
PK-Merz is an antiparkinsonian and antiviral drug, a tricyclic symmetric adamantanamin.
This medication blocks glutamate NMDA-receptors, thus reducing the excessive stimulatory effect of cortical glutamate neurons in the neostriatum that develops against the backdrop of lack of dopamine. PK-Merz inhibits NMDA-receptors in the neurons of the substantia nigra reduces the intake of these Ca2+, which reduces the possibility of destruction of these neurons. In a greater PK-Merz influences on stiffness.
This medicine inhibits the penetration of influenza A virus into the cell.
Pharmacokinetics
PK-Merz after oral administration is completely absorbed from the gastrointestinal tract. Cmax plasma levels achieved after 5 hours. This medication excreted in urine. T1/2 of PK-Merz sulfate is 12-13 hours, in contrast to PK-Merz hydrochloride, which T1/2 is 30 hours.
Why is PK-Merz prescribed?
Parkinson's disease, Parkinson's syndrome.
Neuralgia in Herpes Zoster, caused by the virus Varicella Zoster.
Prevention (including in combination with vaccination) and treatment of influenza A.
Dosage and administration
For oral administration the single dose is 100-200 mg.
IV in the form of infusion in 200 mg during 3 hours.
The frequency and duration of PK-Merz use depends on the evidence, the patient's response to treatment, the epidemiological situation.
The maximum dose for oral administration is 600 mg / day.
PK-Merz side effects, adverse reactions
CNS: headaches, depression, visual hallucinations, motor or mental excitement, convulsions, irritability, dizziness, sleep disturbances, tremors, mental disorders are accompanied by visual hallucinations, reduced visual acuity.
Cardiovascular system: the development or exacerbation of heart failure, orthostatic hypotension; rarely - arrhythmia, tachycardia.
Digestive system: rarely - anorexia, nausea, constipation, dry mouth.
Urinary system: patients with benign prostatic hyperplasia - difficulty urinating; polyuria, nocturia.
Dermatological reactions: dermatitis, the appearance of a bluish color of the skin of the upper and lower extremities.
PK-Merz contraindications
Hepatic failure, chronic renal failure, psychosis (including history), hyperthyroidism, epilepsy, angle-closure glaucoma, prostatic hyperplasia, hypotension, congestive heart failure stage II-III, excited, preddeliry, delirious psychosis, I trimester of pregnancy, lactation, concomitant use of triamterene and hydrochlorothiazide, increased sensitivity to PK-Merz.
Using during pregnancy and breastfeeding
The use of PK-Merz in pregnancy is possible only under strict indications and under the supervision of a physician.
If necessary to use during lactation it been should decide on the termination of breastfeeding.
Category of the fetus by FDA - C.
Special instructions
Use PK-Merz with caution in patients with impaired renal function, while taking other antiparkinsonian drugs, as well as in the elderly. In such cases a correction of the dosage of PK-Merz is needed. Patients with hyperreflexia the cancellation of treatment should be gradual.
An information about the effectiveness of PK-Merz to reduce extrapyramidal disorders during treatment with antipsychotic drugs are contradictory.
During treatment avoid drinking alcohol.
In the period of treatment you should not engage in activities that require high concentration and rapid psychomotor reactions.
PK-Merz drug interactions
When this drug applied simultaneously with:
- may increase the side effects of other antiparkinsonian medications.
- thiazide diuretics can not been excluded the possibility of toxic effects of PK-Merz (ataxia, agitation, hallucinations), probably by reducing its renal clearance.
- quinine, quinidine may decrease the excretion of PK-Merz in urine.
There was described a case of acute confusion in elderly patients while this medication was simultaneously used with co-trimoxazole.
PK-Merz pharmaceutical active ingredients containing related brand and generic drugs:
PK-Merz available forms, composition, doses:
PK-Merz destination | category:
PK-Merz Anatomical Therapeutic Chemical codes:
PK-Merz pharmaceutical companies:
References
- "amantadine". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
- "amantadine". http://www.drugbank.ca/drugs/DB0091... (accessed August 28, 2018).
- "BF4C9Z1J53: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Dat... (accessed August 28, 2018).
Frequently asked Questions
Can i drive or operate heavy machine after consuming PK-Merz?Depending on the reaction of the PK-Merz after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider PK-Merz not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.
Is PK-Merz addictive or habit forming?Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
Review
sdrugs.com conducted a study on PK-Merz, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of PK-Merz consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.Visitor reports
Visitor reported useful
No survey data has been collected yetVisitor reported side effects
No survey data has been collected yetOne visitor reported price estimates
What is your opinion about drug cost? Did you feel the cost is apt, or did you feel it is expensive?The report given by the sdrugs.com website users shows the following figures about several people who felt the medicine PK-Merz is expensive, and the medicine is not expensive. The results are mixed. The perception of the cost of the medicine to be expensive or not depends on the brand name of the medicine, country, and place where it is sold, and the affordability of the patient. You can choose a generic drug in the place of the branded drug to save the cost. The efficiency of the medicine will not vary if it is generic or a branded one.
| Visitors | % | ||
|---|---|---|---|
| Expensive | 1 | 100.0% | |
Three visitors reported frequency of use
How often in a day do you take the medicine?Are you taking the PK-Merz drug as prescribed by the doctor?
Few medications can be taken 4 times in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sdrugs.com website users about the frequency of taking the drug PK-Merz is mentioned below.
| Visitors | % | ||
|---|---|---|---|
| 4 times in a day | 1 | 33.3% | |
| Once in a day | 1 | 33.3% | |
| Twice in a day | 1 | 33.3% | |
Five visitors reported doses
What is the dose of PK-Merz drug you are taking?According to the survey conducted among sdrugs.com website users, the maximum number of people are using the following dose 51-100mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
| Visitors | % | ||
|---|---|---|---|
| 51-100mg | 4 | 80.0% | |
| 201-500mg | 1 | 20.0% | |
Four visitors reported time for results
What is the time duration PK-Merz drug must be taken for it to be effective or for it to reduce the symptoms?Most chronic conditions need at least some time so the dose and the drug action gets adjusted to the body to get the desired effect. The stastistics say sdrugs.com website users needed > 3 month to notice the result from using PK-Merz drug. The time needed to show improvement in health condition after using the medicine PK-Merz need not be same for all the users. It varies based on other factors.
| Visitors | % | ||
|---|---|---|---|
| > 3 month | 3 | 75.0% | |
| 1 week | 1 | 25.0% | |
Three visitors reported administration
The drugs are administered in various routes, like oral or injection form. They are administered before food or after food. How are you taking PK-Merz drug, before food or after food?Click here to find out how other users of our website are taking it. For any doubts or queries on how and when the medicine is administered, contact your health care provider immediately.
| Visitors | % | ||
|---|---|---|---|
| After food | 2 | 66.7% | |
| Empty stomach | 1 | 33.3% | |
Six visitors reported age
| Visitors | % | ||
|---|---|---|---|
| > 60 | 6 | 100.0% | |
Visitor reviews
There are no reviews yet. Be the first to write one! |
The information was verified by Dr. Rachana Salvi, MD Pharmacology